Gene: Cnot4

Name
CCR4-NOT transcription complex, subunit 4
MGI ID
MGI:1859026
Synonyms
Not4hp Not4h Not4
Viability
Homozygous - Lethal
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Cnot4tm1b(EUCOMM)Wtsi HOM n/a 0.00
decreased food intake Cnot4tm1b(EUCOMM)Wtsi HET postnatal 7.02×10-09
decreased lean body mass Cnot4tm1b(EUCOMM)Wtsi HET postnatal 4.47×10-08
decreased total body fat amount Cnot4tm1b(EUCOMM)Wtsi HET postnatal 7.31×10-07
increased total body fat amount Cnot4tm1b(EUCOMM)Wtsi HET postnatal 4.09×10-07
increased bone mineral content Cnot4tm1b(EUCOMM)Wtsi HET postnatal 1.19×10-08
abnormal epidermal immune compartment Cnot4tm1b(EUCOMM)Wtsi HET postnatal 0.00
decreased bone mineral content Cnot4tm1b(EUCOMM)Wtsi HET postnatal 1.19×10-08
decreased body length Cnot4tm1b(EUCOMM)Wtsi HET postnatal 1.85×10-05
increased lean body mass Cnot4tm1b(EUCOMM)Wtsi HET postnatal 4.47×10-08
abnormal bone structure Cnot4tm1b(EUCOMM)Wtsi HET postnatal 4.41×10-07
decreased caudal vertebrae number Cnot4tm1b(EUCOMM)Wtsi HET postnatal 0.00
decreased circulating alkaline phosphatase level Cnot4tm1b(EUCOMM)Wtsi HET postnatal 3.56×10-08
decreased KLRG1+ CD8 alpha beta T cell number Cnot4tm1b(EUCOMM)Wtsi HET postnatal 2.09×10-05

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No  (2/2) N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (1/2) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
LacZ Section Images

View all 7 images

View all 6 images

No Embryo expression data was found for this gene.

 Associated Images

Eye Morphology: Images Slit Lamp
2 Images
X-ray: XRay Images Dorso Ventral
42 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
X-ray: XRay Images Forepaw
14 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
X-ray: XRay Images Lateral Orientation
28 Images
Anti-nuclear antibody assay
6 Images
DSS Histology
8 Images
Legacy Phenotype Associated Images

View all 105 images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Cnot4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cnot4tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Cnot4tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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